According to the World Health Organization, more than 5% of the global population (360 million people) have incapacitating hearing loss, and approximately one third of over 65s are impacted. Hearing loss impacts quality of life and has significant health, social and economic consequences.
Two of the main causes of hearing loss are excessive noise and aging. It was recently discovered that these hearing disorders are sensorineural and that hearing aids and implants are useless in most of these cases. New treatments are required.
Dr. Nevoux aims to identify molecules likely to stimulate auditory neuron growth. A number of molecules will be tested in mice with distorted neuronal connections. Different doses of molecules and routes of administration will be evaluated. Once the optimal dosage and best route of administration are found, their impact on the mice’s hearing will be explored. Any side effects of the identified molecules will also be investigated.
The results will pave the way for new therapeutic approaches to hearing loss linked to auditory nerve damage.
Doctor Jérôme Nevoux
ENT surgeon, Bicêtre University Hospital, Le Kremlin-Bicêtre, France
In Postdoctoral fellowship, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Related scientific publication(s) :
- Jérôme Nevoux, Mihaela Alexandru, Thomas Bellocq, Lei Tanaka, Yushi Hayashi, Takahisa Watabe, Hanae Lahlou, Kohsuke Tani, Albert S B Edge. An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure. Sci Rep. 2021 Feb 3;11(1):2937. doi: 10.1038/s41598-021-81294-5.