PETIT Christine
2019
Christine Petit heads the “Basic Molecular Mechanisms of Hearing and Precision Medicine” unit, whose goals are:
- To advance knowledge in the field of molecular complexes and networks involved in the major functions of sensory cells for hearing.
To develop precision medicine in two fields: diagnostic tools for hearing disorders and the development of curative treatments.
Professor Christine Petit
Investigator - Team leader
Institut de l'Audition, Paris, France
2016 Postdoctoral fellowship
How does the brain adapt when it receives an out-of-sync sound?
Sound perception involves both our ears. A sound from the right-hand side will arrive faster and stronger in the right ear than the left ear. As part of his post-doctoral project supervised by Prof. Christine Petit, Dr. Victor Benichoux will examine how the brain adapts when our two ears receive the same sound out of sync, a situation often observed in hearing disorders.
Professor Christine Petit
Director of the Genetics & Physiology Laboratory of Hearing, Institut Pasteur, Paris, France
Related scientific publication(s) :
- Delmaghani S, Defourny J, Aghaie A, Beurg M, Dulon D, Thelen N, Perfettini I, Zelles T, Aller M, Meyer A, Emptoz A, Giraudet F, Leibovici M, Dartevelle S, Soubigou G, Thiry M, Vizi ES, Safieddine S, Hardelin JP, Avan P, Petit C. Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes. Cell. 2015 Nov 5;163(4):894-906. doi: 10.1016/j.cell.2015.10.023.
- Paul Avan, Sébastien Le Gal, Vincent Michel, Typhaine Dupont, Jean-Pierre Hardelin, Christine Petit, Elisabeth Verpy. Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25948-25957. doi: 10.1073/pnas.1902781116. Epub 2019 Nov 27.
- Jean Defourny, Alain Aghaie, Isabelle Perfettini, Paul Avan, Sedigheh Delmaghani, Christine Petit. Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8010-8017. doi: 10.1073/pnas.1821844116. Epub 2019 Apr 1.
- Margot Tertrais, Yohan Bouleau, Alice Emptoz, Séverin Belleudy, R Bryan Sutton, Christine Petit, Saaid Safieddine, Didier Dulon. Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice. J Neurosci. 2019 May 1;39(18):3394-3411. doi: 10.1523/JNEUROSCI.1550-18.2018. Epub 2019 Mar 4.
- Vincent Michel, Elise Pepermans, Jacques Boutet de Monvel, Patrick England, Sylvie Nouaille, Alain Aghaie, Florent Delhommel, Nicolas Wolff, Isabelle Perfettini, Jean-Pierre Hardelin, Christine Petit, Amel Bahloul. Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells. Sci Rep. 2020 Oct 2;10(1):16430. doi: 10.1038/s41598-020-73158-1.
- Boucher S, Wong Jun Tai F, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C. Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis. Proc Natl Acad Sci U S A. 2020 Nov 23:202010782. doi: 10.1073/pnas.2010782117.
- Nicolas Michalski, Christine Petit. Central auditory deficits associated with genetic forms of peripheral deafness. Hum Genet. 2022 Apr;141(3-4):335-345. doi: 10.1007/s00439-021-02339-3. Epub 2021 Aug 25.