JARYSTA Amandine
Project status: closed
Project : Explaining the role of Daple and Girdin proteins in manufacturing sensorineural cells
Hearing is a complex process initiated when sound vibrations are detected by the sensorineural cells, also known as hair cells, in the inner ear.
Hearing loss, the most common birth defect in developed countries, is mainly due to genetic mutations impacting the proteins forming hair cells. Among these are G proteins. Mice with abnormal G proteins experience difficulty in manufacturing functional hair cells and present early profound hearing loss.
Two other proteins, Daple and Girdin, are capable of regulating G proteins in other contexts, such as cancer. Their role in manufacturing hair cells is not yet known. Dr. Amandine Jarysta will examine this question during her postdoctoral work.
Before envisaging therapies for repairing hair cells and restoring healthy hearing, it is essential to understand how these cells form and develop. Research into Daple and Gardin proteins will determine whether they play a role in the creation of inner hair cells.
Docteur Amandine Jarysta
Postdoctoral researcher
The Jackson Laboratory, Bar Harbor (ME), USA
Related scientific publication(s):
- Amandine Jarysta, Basile Tarchini. Multiple PDZ domain protein maintains patterning of the apical cytoskeleton in sensory hair cells. Development. 2021 Jul 15;148(14):dev199549. doi: 10.1242/dev.199549. Epub 2021 Jul 21.
- Katie S Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, Basile Tarchini. EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia. Nat Commun. 2021 May 17;12(1):2861. doi: 10.1038/s41467-021-22997-1.