EDGE Albert

2018 Master studentship

Project status: closed

Nervous regeneration after acoustic trauma.

The two main causes of hearing loss are acoustic trauma and presbycusis (age-related hearing loss). These are probably due to deteriorated innervation of the hair calls, or the inner ear cells involved in hearing. During her second-year master’s internship in the laboratory of Professor Albert Edge, Dr. Alexandru will analyze the potential of two proteins for nerve regeneration between the hair cells and the neurons of the acoustic nerve: the repulsive guidance molecule (RGMa) and the bone morphogenic protein (BMP). This research will explore new therapeutic avenues for hearing loss related to nerve damage.

2016 Postdoctoral fellowship

Project status: closed

New potential for treating hearing loss: regeneration of auditory neurons.

Dr. Jérôme Nevoux will explore new therapeutic avenues for hearing loss by attempting to identify molecules stimulating the growth of auditory neurons during his postdoctoral work at the Eaton-Peabody Laboratory at the Massachusetts Eye and Ear Infirmary.

The results of this work will offer new potential for the treatment of hearing loss related to neuronal damage in humans.

Professor Albert Edge
Supervisor of the postdoctoral fellowship of Dr. Nevoux
Massachusetts Eye and Ear Infirmary, Boston, USA

Related scientific publication(s):

• Jérôme Nevoux , Mihaela Alexandru, Thomas Bellocq, Lei Tanaka1, Yushi Hayashi, Takahisa Watabe, Hanae Lahlou, Kohsuke Tani & Albert S. B. Edge. An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure. Sci Rep. 2021 Feb 3;11(1):2937. doi: 10.1038/s41598-021-81294-5.